Human Papillomavirus Vaccine: Its Application and Perspective
نویسندگان
چکیده
Two prophylactic vaccines against HPV16 and 18 infections are commercially available. Published clinical trials with these HPV vaccines report their use in protection against cervical CIN2+ if girls are vaccinated before their sexual debut. Even though HPV 16 and 18 cause approximately 70% of cervical cancer and an almost 100% of effectiveness would be expected against these cancers, other types may frequently cause cervical cancers in aged women > 50 years. Serious adverse events of the vaccine are a matter of public concern in Japan despite a low incidence rate. After the current vaccines have been implemented world-wide, cervical cancer screening must be undertaken with special attention to changing HPV types and age distribution of patients with cervical cancer.
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